Triple-negative breast cancers (TNBC) are proof against standard-of-care chemotherapy and lack identified targetable driver gene alterations. Identification of novel drivers may help the invention of latest therapy methods for this hard-to-treat affected person inhabitants, but research utilizing high-throughput and correct fashions to outline the capabilities of driver genes in TNBC to this point have been restricted. Right here, we employed unbiased practical genomics screening of the 200 most often mutated genes in breast most cancers, utilizing spheroid cultures to mannequin in vivo-like circumstances, and recognized the histone acetyltransferase CREBBP as a novel tumor suppressor in TNBC. CREBBP protein expression in affected person tumor samples was absent in 8% of TNBCs and at a excessive frequency in different tumors, together with squamous lung most cancers, the place CREBBP-inactivating mutations are frequent.
In TNBC, CREBBP alterations have been related to greater genomic heterogeneity and poorer affected person survival and resulted in upregulation and dependency on a FOXM1 proliferative program. Concentrating on FOXM1-driven proliferation not directly with medical CDK4/6 inhibitors (CDK4/6i) selectively impaired development in spheroids, cell line xenografts, and patient-derived fashions from a number of tumor varieties with CREBBP mutations or lack of protein expression. In conclusion, now we have recognized CREBBP as a novel driver in aggressive TNBC and recognized an related genetic vulnerability in tumor cells with alterations in CREBBP and supply a preclinical rationale for assessing CREBBP alterations as a biomarker of CDK4/6i response in a brand new affected person inhabitants.
We cloned one other gene utilizing an affiliation of its presence/absence with pathotypes, and designated it as PWT6. PWT6 was extensively distributed in a lineage composed of Eleusine/Eragrostis isolates, however utterly absent in a lineage composed of Lolium/Triticum isolates. Then again, PWT3 homologs have been current in all isolates, and their lack of operate in Triticum isolates was brought on by insertions of transposable components or nucleotide substitutions. Analyses of entire genome sequences of consultant isolates revealed that these two genes have been positioned in numerous genomic compartments; PWT6 was positioned in a repeat-rich area whereas PWT3 was positioned in a repeat-poor area. These outcomes counsel that the course of differentiation of the pathotypes in P. oryzae seems to be illustrated as processes of practical losses of avirulence genes, however that modes of the losses are affected by genomic compartments by which they reside.
Plastid Transcriptomics: An Vital Device For Plastid Useful Genomics
Plastids in greater vegetation perform specialised roles equivalent to photosynthesis, nitrogen assimilation, biosynthesis of amino acids, fatty acids, isoprenoids, and numerous metabolites. Plastids come up from undifferentiated precursors generally known as proplastids, that are discovered within the root and shoot meristems. They’re extremely dynamic as they modify their quantity, morphology, and physiology in response to the tissue they’re current. Along with housing numerous metabolic actions, plastids additionally function a world sensor for each inside and exterior environmental cues together with totally different stresses, and assist vegetation to reply/alter accordingly.
They relay info to the nucleus, which then responds by altering the expression ranges of particular genes. It has been proven that vegetation with impaired plastid capabilities exhibit abnormalities. One of many sources emanating these indicators to the nucleus is plastid transcription. Regular plastid functioning is subsequently crucial for plant survival. Regardless of immense significance for plant acclimation, the plastid transcriptome is basically an unstudied analysis space. On this evaluate, we talk about the significance of plastid transcriptomics for the acclimation of vegetation underneath altering environmental circumstances and summarize the important thing literature printed on this subject.

New Applied sciences to Examine Useful Genomics of Age-Associated Macular Degeneration
5 Element Oil Standard 900 ug/g (900 PPM) for AA and ICP 100 grams Base Oil 75 |
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AM-900Y | Scientific Laboratory Supplies | 100G | EUR 219.6 |
12 Element Oil Standard 100 ug/g (100 PPM) for AA and ICP 100 grams Base Oil 75 |
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S12-100Y | Scientific Laboratory Supplies | 100G | EUR 369.6 |
12 Element Oil Standard 900 ug/g (900 PPM) for AA and ICP 100 grams Base Oil 75 |
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S12-900Y | Scientific Laboratory Supplies | 100G | EUR 924 |
21 Element Oil Standard 100 ug/g (100 PPM) for AA and ICP 100 grams Base Oil 75 |
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S21-100Y | Scientific Laboratory Supplies | 100G | EUR 199.2 |
21 Element Oil Standard 300 ug/g (300 PPM) for AA and ICP 100 grams Base Oil 75 |
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S21-300Y | Scientific Laboratory Supplies | 100G | EUR 288 |
21 Element Oil Standard 500 ug/g (500 PPM) for AA and ICP 100 grams Base Oil 75 |
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S21-500Y | Scientific Laboratory Supplies | 100G | EUR 454.8 |
21 Element Oil Standard 900 ug/g (900 PPM) for AA and ICP 100 grams Base Oil 75 |
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S21-900Y | Scientific Laboratory Supplies | 100G | EUR 621.6 |
23 Element Oil Standard 100 ug/g (100 PPM) for AA and ICP 100 grams Base Oil 75 |
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S23-100Y | Scientific Laboratory Supplies | 100G | EUR 270 |
23 Element Oil Standard 300 ug/g (300 PPM) for AA and ICP 100 grams Base Oil 75 |
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S23-300Y | Scientific Laboratory Supplies | 100G | EUR 339.6 |
23 Element Oil Standard 500 ug/g (500 PPM) for AA and ICP 100 grams Base Oil 75 |
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S23-500Y | Scientific Laboratory Supplies | 100G | EUR 556.8 |
23 Element Oil Standard 900 ug/g (900 PPM) for AA and ICP 100 grams Base Oil 75 |
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S23-900Y | Scientific Laboratory Supplies | 100G | EUR 1060.8 |
5 Element Oil Standard 1000 ug/g (1000 PPM) for AA and ICP 50 grams Base Oil 75 |
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AM-1000Z | Scientific Laboratory Supplies | 50G | EUR 182.4 |
5 Element Oil Standard 5000 ug/g (5000 PPM) for AA and ICP 50 grams Base Oil 75 |
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AM-5000Z | Scientific Laboratory Supplies | 50G | EUR 561.6 |
5 Element Oil Standard 900 ug/g (900 PPM) for AA and ICP 50 grams Base Oil 75 |
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AM-900Z | Scientific Laboratory Supplies | 50G | EUR 128.4 |
12 Element Oil Standard 100 ug/g (100 PPM) for AA and ICP 50 grams Base Oil 75 |
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S12-100Z | Scientific Laboratory Supplies | 50G | EUR 237.6 |
12 Element Oil Standard 500 ug/g (500 PPM) for AA and ICP 50 grams Base Oil 75 |
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S12-500Z | Scientific Laboratory Supplies | 50G | EUR 422.4 |
12 Element Oil Standard 900 ug/g (900 PPM) for AA and ICP 50 grams Base Oil 75 |
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S12-900Z | Scientific Laboratory Supplies | 50G | EUR 688.8 |
21 Element Oil Standard 100 ug/g (100 PPM) for AA and ICP 50 grams Base Oil 75 |
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S21-100Z | Scientific Laboratory Supplies | 50G | EUR 112.8 |
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S21-300Z | Scientific Laboratory Supplies | 50G | EUR 181.2 |
21 Element Oil Standard 500 ug/g (500 PPM) for AA and ICP 50 grams Base Oil 75 |
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S21-500Z | Scientific Laboratory Supplies | 50G | EUR 261.6 |
21 Element Oil Standard 900 ug/g (900 PPM) for AA and ICP 50 grams Base Oil 75 |
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S21-900Z | Scientific Laboratory Supplies | 50G | EUR 403.2 |
23 Element Oil Standard 100 ug/g (100 PPM) for AA and ICP 50 grams Base Oil 75 |
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S23-100Z | Scientific Laboratory Supplies | 50G | EUR 174 |
23 Element Oil Standard 300 ug/g (300 PPM) for AA and ICP 50 grams Base Oil 75 |
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S23-300Z | Scientific Laboratory Supplies | 50G | EUR 217.2 |
23 Element Oil Standard 500 ug/g (500 PPM) for AA and ICP 50 grams Base Oil 75 |
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S23-500Z | Scientific Laboratory Supplies | 50G | EUR 361.2 |
23 Element Oil Standard 900 ug/g (900 PPM) for AA and ICP 50 grams Base Oil 75 |
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S23-900Z | Scientific Laboratory Supplies | 50G | EUR 474 |
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5 Element Biodiesel Standard 5 ug/g (5 PPM) for AA and ICP 100 grams B100 Biofuel |
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BFM-20Y | Scientific Laboratory Supplies | 100ML | EUR 214.8 |
5 Element Biodiesel Standard 20 ug/g (20 PPM) for AA and ICP 100 grams B100 Biofuel |
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BFM-5Y | Scientific Laboratory Supplies | 100ML | EUR 214.8 |
ICP-MS Internal Standard 1 |
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CLISS-1 | Scientific Laboratory Supplies | 125ML | EUR 253.29 |
AAS Multi Element (13) Std at 10ug/mL |
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AAMIX13A | Scientific Laboratory Supplies | 100ML | EUR 336 |
AAS Multi Element (13) Std at 100ug/mL |
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AAMIX13B | Scientific Laboratory Supplies | 100ML | EUR 404.4 |
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FPLE5 | Scientific Laboratory Supplies | 500ML | EUR 416.4 |
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FPHE5 | Scientific Laboratory Supplies | 500ML | EUR 423.01 |
ICP Standard Phosphorus H2O |
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PP2A7 | Scientific Laboratory Supplies | 100ML | EUR 220.8 |
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FPME5 | Scientific Laboratory Supplies | 500ML | EUR 423.01 |
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PZN2A3 | Scientific Laboratory Supplies | 100ML | EUR 120.12 |
ICP-MS Instrument Check Standard 1 |
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CL-ICS-1 | Scientific Laboratory Supplies | 125ML | EUR 410.4 |
ICP-MS Alternate Internal Standard 1 |
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CL-ISM1-100 | Scientific Laboratory Supplies | 125ML | EUR 292.45 |
ICP-MS Alternate Internal Standard 1 |
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CL-ISM1-500 | Scientific Laboratory Supplies | 500ML | EUR 417.79 |
ICP-MS Internal Standard 2 |
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CLISS-2 | Scientific Laboratory Supplies | 125ML | EUR 389.07 |
ICP Standard Manganese 2-5pc |
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PMN2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Standard Beryllium 2-5pc |
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PBE2A2 | Scientific Laboratory Supplies | 100ML | EUR 211.2 |
ICP Standard Strontium 2-5pc |
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PSR2A2 | Scientific Laboratory Supplies | 100ML | EUR 221.95 |
ICP Standard Vanadium 2pc HNO3 |
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PV2A19 | Scientific Laboratory Supplies | 100ML | EUR 169.2 |
ICP Quality Control Standard 21 |
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QC-21 | Scientific Laboratory Supplies | 125ML | EUR 422.4 |
ICP Quality Control Standard 21 |
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QC-21-250 | Scientific Laboratory Supplies | 250ML | EUR 567.6 |
ICP Quality Control Standard 21 |
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QC-21-500 | Scientific Laboratory Supplies | 500ML | EUR 704.4 |
ICP Quality Control Standard 22 |
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QC-22 | Scientific Laboratory Supplies | 125ML | EUR 550.8 |
ICP Quality Control Standard 22 |
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QC-22-250 | Scientific Laboratory Supplies | 250ML | EUR 579.6 |
ICP Quality Control Standard 22 |
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QC-22-500 | Scientific Laboratory Supplies | 500ML | EUR 715.2 |
ICP Quality Control Standard 23 |
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QC-23 | Scientific Laboratory Supplies | 125ML | EUR 673.2 |
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QC-24 | Scientific Laboratory Supplies | 125ML | EUR 550.8 |
ICP Quality Control Standard 7 |
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QC-7 | Scientific Laboratory Supplies | 125ML | EUR 223.2 |
ICP Quality Control Standard 7 |
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QC-7-500 | Scientific Laboratory Supplies | 500ML | EUR 374.4 |
ICP Quality Control Standard 7A |
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QC-7A | Scientific Laboratory Supplies | 125ML | EUR 219.6 |
ICP-MS Instrument Calibration Standard 1 |
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CL-CAL-1 | Scientific Laboratory Supplies | 125ML | EUR 454.8 |
ICP Instrument Check Standard 10 |
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CALMIX10-100 | Scientific Laboratory Supplies | 125ML | EUR 228 |
ICP Instrument Check Standard 10 |
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CALMIX10-500 | Scientific Laboratory Supplies | 500ML | EUR 385.2 |
ICP Instrument Check Standard 3 |
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CALMIX3-100 | Scientific Laboratory Supplies | 125ML | EUR 274.8 |
ICP Instrument Check Standard 3 |
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ICP Instrument Check Standard 4 |
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CALMIX4-100 | Scientific Laboratory Supplies | 125ML | EUR 288 |
ICP Instrument Check Standard 4 |
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CALMIX4-500 | Scientific Laboratory Supplies | 500ML | EUR 469.2 |
ICP Instrument Check Standard 7 |
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CALMIX7-100 | Scientific Laboratory Supplies | 125ML | EUR 309.6 |
ICP Instrument Check Standard 7 |
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CALMIX7-500 | Scientific Laboratory Supplies | 500ML | EUR 535.2 |
ICP Instrument Check Standard 8 |
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CALMIX8-500 | Scientific Laboratory Supplies | 500ML | EUR 367.2 |
ICP-MS Calibration Standard 3 |
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CL-CAL-3 | Scientific Laboratory Supplies | 125ML | EUR 154.8 |
ICP Qualicty Control Standard 7A |
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QC-7A-500 | Scientific Laboratory Supplies | 500ML | EUR 363.6 |
ICP Standard Tin In 10pc HCl |
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PSN2A13 | Scientific Laboratory Supplies | 100ML | EUR 226.8 |
ICP Interference Check Standard 5 |
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INTER5-100 | Scientific Laboratory Supplies | 125ML | EUR 295.2 |
ICP Interference Check Standard 5 |
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INTER5-500 | Scientific Laboratory Supplies | 500ML | EUR 501.6 |
AAS Multi Element Std Cd Pb Ni at 1000ppm in 2% HNO3 |
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AA-BIB-3-100 | Scientific Laboratory Supplies | 100ML | EUR 188.01 |
AAS Multi Element Std Cd Pb Ni at 1000ppm in 2% HNO3 |
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AA-BIB-3-500 | Scientific Laboratory Supplies | 500ML | EUR 270.26 |
AAS Multi Element (16) Std at 1mg/L each in 5% HNO3 |
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AAS16-100 | Scientific Laboratory Supplies | 100ML | EUR 193.23 |
AAS Multi Element (16) Std at 1mg/L each in 5% HNO3 |
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AAS16-250 | Scientific Laboratory Supplies | 250ML | EUR 345.98 |
AAS Multi Element (16) Std at 1mg/L each in 5%HNO3 |
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AAS16-500 | Scientific Laboratory Supplies | 500ML | EUR 432.15 |
ICP Standard Sodium 2-5pc HNO3 |
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PNA2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Standard Lithium 2-5pc HCl |
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PLI2A3 | Scientific Laboratory Supplies | 100ML | EUR 120.12 |
ICP Standard Barium 2-5pc HNO3 |
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PBA2A2 | Scientific Laboratory Supplies | 100ML | EUR 220.8 |
ICP Standard Cobalt 2-5pc HNO3 |
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PCO2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Standard Boron H2O 1000ug-ml |
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PB2A7 | Scientific Laboratory Supplies | 100ML | EUR 220.8 |
ICP Standard Lithium 2-5pc HNO3 |
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PLI2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Standard Molybdenum H2O 1000ug/ml |
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PMO2A7 | Scientific Laboratory Supplies | 100ML | EUR 132 |
ICP-MS Quality Control Standard 21 |
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CL-QC-21 | Scientific Laboratory Supplies | 125ML | EUR 483.6 |
Flame Multi Element Linearity Std Low Medium and High Con |
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FPHK3 | Scientific Laboratory Supplies | 500ML | EUR 882 |
ICP-MS Instrument Check Standard 3 |
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CL-ICS-3 | Scientific Laboratory Supplies | 125ML | EUR 225.6 |
ICP-MS Instrument Check Standard 4 |
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CL-ICS-4 | Scientific Laboratory Supplies | 125ML | EUR 150 |
ICP-MS Instrument Check Standard 5 |
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CL-ICS-5 | Scientific Laboratory Supplies | 125ML | EUR 166.8 |
ICP Standard Mercury 10% HNO3 1000µg/ml |
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PHG2A6 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP-MS Alternate Internal Standard 2 |
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CL-ISM2-100 | Scientific Laboratory Supplies | 125ML | EUR 463.49 |
ICP-MS Initial Calibration Verification Standard 1 |
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CL-ICV-1 | Scientific Laboratory Supplies | 125ML | EUR 487.2 |
ICP Standard Lead 2-5% HNO3 1000µg/ml |
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PPB2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Standard Iron 2-5% HNO3 1000µg/ml |
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PFE2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP-MS Instrument Calibration Standard 2 |
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CL-CAL-2 | Scientific Laboratory Supplies | 125ML | EUR 486 |
ICP Standard Nickel 2-5% HNO3 1000µg/ml |
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PNI2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Standard Copper 2-5% HNO3 1000µg/ml |
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PCU2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Standard Silver 2-5% HNO3 1000ug/ml |
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PAG2A2 | Scientific Laboratory Supplies | 100ML | EUR 330 |
Multi-State Hydrocarbon Standard Hexane through Tetratetracontane Even Alkanes (High Level) |
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PROALK6-44-H | Scientific Laboratory Supplies | 1ML | EUR 166.8 |
ICP Standard Chromium 2-5% HNO3 1000µg/ml |
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PCR2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
Icp Standard Calcium 2-5% Hn03 1000ug/ml |
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PCA2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
Icp Standard Cadmium 2-5% Hno3 1000ug/ml |
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PCD2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Standard Magnesium 2-5% HNO3 1000µg/ml |
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PMG2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Standard Aluminum 2-5% HNO3 1000ug/ml |
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PAL2A2 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Standard Selenium 2-5% HNO3 1000ug/ml |
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PSE2A2 | Scientific Laboratory Supplies | 100ML | EUR 220.8 |
ICP Standard Potassium 2-5% HNO3 1000ug/ml |
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PK2A2 | Scientific Laboratory Supplies | 100ML | EUR 220.8 |
ICP Standard Antimony Plus Tr HNO3 1000ug/ml |
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PSB2A4 | Scientific Laboratory Supplies | 100ML | EUR 120 |
ICP Interference Check Standard 18 without Mercury |
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INTER18-100N | Scientific Laboratory Supplies | 125ML | EUR 436.8 |
ICP Interference Check Standard 18 without Mercury |
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INTER18-500N | Scientific Laboratory Supplies | 500ML | EUR 750 |
ICP-MS Multi-Element Solution 1 |
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CLMS-1 | Scientific Laboratory Supplies | 125ML | EUR 369.6 |
ICP Multi Elem (10) Std in 1% HCl |
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ICP10-STATION-1 | Scientific Laboratory Supplies | 100ML | EUR 547.05 |
ICP Multi Elem (10) Std in 1% HCl |
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ICP10-STATION-2 | Scientific Laboratory Supplies | 100ML | EUR 547.05 |
ICP Multi Elem (18) Std in 5% |
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ICP-JM-ME10A | Scientific Laboratory Supplies | 500ML | EUR 621.47 |
ICP-MS Multi-Element Solution 2 |
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CLMS-2 | Scientific Laboratory Supplies | 125ML | EUR 516 |
ICP-MS Multi-Element Solution 3 |
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CLMS-3 | Scientific Laboratory Supplies | 125ML | EUR 660 |
ICP-MS Multi-Element Solution 4 |
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CLMS-4 | Scientific Laboratory Supplies | 125ML | EUR 282 |
ICP-MS Multi-Element Solution 5 |
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CLMS-5 | Scientific Laboratory Supplies | 125ML | EUR 205.2 |
ICP Multi Elem (3) in 2% HNO3 |
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ICP-MIX10 | Scientific Laboratory Supplies | 125ML | EUR 231.09 |
ICP Multi Elem (18) Std 5% HNO3 |
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ICP18-MIX-2 | Scientific Laboratory Supplies | 1L | EUR 2088 |
ICP Multi Elem (9) Std 1000mg/L |
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ICPMIX-9-100 | Scientific Laboratory Supplies | 100ML | EUR 279.4 |
ICP-MS Quality Control Standard 21 in 5% HNO3/Tr.Tart. Acid/TR HF |
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CL-QC-21A | Scientific Laboratory Supplies | 125ML | EUR 453.6 |
ICP ICP-MS Multi Elem (8) Std in 7% HNO3 USP 232 |
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REICPUSP3 | Scientific Laboratory Supplies | 100ML | EUR 177.56 |
ICP ICP-MS Multi Elem (8) Std in 7% HNO3 USP 232 |
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REICPUSP6 | Scientific Laboratory Supplies | 100ML | EUR 177.56 |
ICP ICP-MS Multi Elem (4) Std in 7% HNO3 USP 2232 |
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REICPUSP7 | Scientific Laboratory Supplies | 100ML | EUR 133.17 |
Peptide Standard 1 |
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5-01747 | CHI Scientific | 4 x 1mg | Ask for price |
ICP Multi Elem (18) Std in 5% HCl |
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ICP-JM-ME4A | Scientific Laboratory Supplies | 500ML | EUR 733.75 |
ICP Multi Elem (11) Std in 2% HCl |
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ICP11-MIX-100 | Scientific Laboratory Supplies | 100ML | EUR 569.24 |
Standard |
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abx098954-10vials | Abbexa | 10 vials | EUR 2614.8 |
Standard |
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abx098954-1vial | Abbexa | 1 vial | EUR 360 |